Dry eye and ocular surface disease
نویسندگان
چکیده
منابع مشابه
Lacrimal Gland, Ocular Surface, and Dry Eye
1Pharmacology & Pharmaceutical Sciences, USC Eye Institute, University of Southern California, Los Angeles, CA, USA 2Pharmacology and Pharmacotherapy, Ophthalmology, University of Szeged, Szeged, Hungary 3Ophthalmology, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing, China 4Singapore Eye Research Institute, Singapore 5Department of Ophthalmology, Yong Loo Lin School of Me...
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Keratoconjunctivitis sicca, or dry eye, is a common ocular disease prompting millions of individuals to seek ophthalmological care. Regardless of the underlying etiology, dry eye has been shown to be associated with abnormalities in the pre-corneal tear film and subsequent inflammatory changes in the entire ocular surface including the adnexa, conjunctiva and cornea. Since the recognition of th...
متن کاملDry Eye Management: Targeting the Ocular Surface Microenvironment
Dry eye can damage the ocular surface and result in mild corneal epithelial defect to blinding corneal pannus formation and squamous metaplasia. Significant progress in the treatment of dry eye has been made in the last two decades; progressing from lubricating and hydrating the ocular surface with artificial tear to stimulating tear secretion; anti-inflammation and immune regulation. With the ...
متن کاملClusterin Seals the Ocular Surface Barrier in Mouse Dry Eye
Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model for desiccating ...
متن کاملApoptosis of ocular surface cells in experimentally induced dry eye.
PURPOSE To evaluate to effect of experimental dry eye on ocular surface apoptosis. METHODS Aqueous tear production and clearance were inhibited by systemic administration of scopolamine and exposure to an air draft for 12 days in 4- to 6-week-old 129SvEv/CD-1 mixed white mice. Eyes and ocular adnexa were excised, cryosectioned, and evaluated for apoptosis by terminal deoxynucleotidyl transfer...
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ژورنال
عنوان ژورنال: Saudi Journal of Ophthalmology
سال: 2014
ISSN: 1319-4534
DOI: 10.1016/j.sjopt.2014.09.003